The guide RNA may be engineered to have complementarity to a target sequence of interest in the genome, e.g., a sequence in any gene or intergenic region of interest. In many embodiments, a variant shares at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, or more global sequence identity or similarity with the original protein. comprises on the cell surface, at least one exogenous antigenic polypeptide, wherein the exogenous antigenic polypeptide is LIYRRRLMK (SEQ ID NO: 316), wherein the erythroid cell further presents, e.g. For example, the detergent may be saponin. In some embodiments, the anchor is a GPI-linked protein. Tail does not make complete, rotations around the body axis (“helicopter”). Alternatively, the first, second and third anti-cancer therapeutic can act on different targets. In some embodiments, the exogenous antigenic polypeptide is bound to the exogenous antigen-presenting polypeptide. develops biofilms. The results of the experiment are represented in FIG. In some embodiments, the erythroid cell is an enucleated cell. In another embodiment, the Treg costimulatory polypeptides stimulate two of these signals. A chemokine, including a homologue, variant, mutant or fragment thereof, encompasses an alpha-chemokine or a beta-chemokine, including, but not limited to, a C5a, interleukin-8 (IL-8), monocyte chemotactic protein 1alpha (MIP1a), monocyte chemotactic protein 1 beta (MIP1β), monocyte chemoattractant protein 1 (MCP-1), monocyte chemoattractant protein 3 (MCP-3), platelet activating factor (PAFR), N-formyl-methionyl-leucyl-[3H]phenylalanine (FMLPR), leukotriene B4 (LTB4R), gastrin releasing peptide (GRP), RANTES, eotaxin, lymphotactin, IP10, 1-309, ENA78, GCP-2, NAP-2 and/or MGSA/gro. comprises on the cell surface, an exogenous polypeptide comprising a costimulatory polypeptide. The relative amounts of the active ingredient, the pharmaceutically acceptable carrier, and any additional ingredients in a pharmaceutical composition of the disclosure will vary, depending upon the identity, size, and condition of the subject treated and further depending upon the route by which the composition is to be administered. BAFT has been shown to be a central regulator of early effector CD8+ T cell differentiation. In embodiments, a single unit dose of engineered erythroid cells can comprise, in various embodiments, at least about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% engineered erythroid cells, wherein the remaining erythroid cells in the dose are not engineered. Optionally, the antigen is provided as part of an MHC/antigen complex. In some embodiments, the exogenous antigen-presenting polypeptide is an MHC class I polypeptide, an MHC class I single chain fusion, an MHC class II polypeptide, or an MHC class II single chain fusion.

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